Which of the following would be most suggestive of adenocarcinoma?

A 50 year-old woman with a family history of breast cancer has a lumpectomy after a breast mass is identified during screening mammography. If pathological, histological, and cytogenetic studies were performed, which of the following would be most suggestive of adenocarcinoma?

1.Desmoplastic surrounding tissues
2.Encapsulated tumor
3.Polyclonality
4.Predominantly interphase cells
5.Well differentiated cells

exp:

Adenocarcinoma is commonly associated with desmoplasia, a tumor-induced proliferation of non-neoplastic fibrous connective tissue which surrounds the tumor. It is seen most commonly in adenocarcinoma of the breast, pancreas, and prostate.