Which single factor is a sign of alcohol dependence?

A 61-year-old man attends his GP at the request of his wife who thinks he drinks too much alcohol. Which single factor is a sign of alcohol dependence?

A. A wide repertoire of alcohol drinks
B. Decreased tolerance to alcohol
C. Drinking 28 units of alcohol once a week
D. Drinking despite evidence of its harm to job and family
E. Drinking until late in the evening

Ans: D. Drinking despite evidence of its harm to job and family