Why progesterone decreasing drugs like Mifepristone and Ulipristal is given in hyperestrogenic conditions like Fibroid?

Why progesterone decreasing drugs like Mifepristone and Ulipristal is given in hyperestrogenic conditions like Fibroid?

Progesterone-modulating drugs like mifepristone and ulipristal acetate are used in hyperestrogenic conditions such as uterine fibroids for the following reasons:

  1. Antiproliferative Effect: Mifepristone and ulipristal acetate can inhibit the proliferation of fibroid cells. By blocking the action of progesterone, these drugs reduce the growth of fibroids, which are often driven by both estrogen and progesterone.
  2. Reduction of Symptoms: These drugs can help reduce the symptoms associated with fibroids, such as heavy menstrual bleeding and pelvic pain. By modulating the hormonal environment, they can help shrink the size of the fibroids and decrease bleeding.
  3. Inducing Apoptosis: Progesterone antagonists can promote apoptosis (programmed cell death) in fibroid cells, contributing to a reduction in fibroid size.
  4. Endometrial Effects: These drugs can also affect the endometrium (lining of the uterus), potentially reducing abnormal uterine bleeding, which is a common symptom of fibroids.
  5. Improving Surgical Outcomes: In some cases, these medications are used preoperatively to shrink fibroids and reduce blood loss during surgery, making surgical removal easier and safer.

By addressing both the estrogen and progesterone pathways, these medications provide a more comprehensive approach to managing fibroids, which are influenced by multiple hormonal factors.