Why there is epinephrine in centrilobular hepatocytes, in dubin johnson?

why there is epinephrine in centrilobular hepatocytes, in dubin johnson?

Most likely due to defective biliary excretion of epinephrine metabolites; which also imparts the characteristic black pigmentation of liver in this conjugated hyperbilirubinemia syndrome.

Hi Gopal Pal, Epinephrine metabolites, i.e., tyrosine, phenylalanine and tryptophan metabolites, such as metanephrine, are normally secreted in bile as organic anions. In Dubin-Johnson, there is a mutation in the MRP2 gene. MRP2 is responsible for the canalicular secretion of non-bile-acid organic anions. As a result, there is an increased deposition of epinephrine metabolites in Dubin Johnson syndrome, giving the liver its characteristic black appearance. Thank you.