Why there is microcytosis in polycythemia rubra vera inspite of increased size of RBCs (low ESR)
In Polycythemia Rubra Vera (PRV), microcytosis (smaller than normal red blood cells) is not a typical finding. In fact, PRV is characterized by an increase in the total number of red blood cells (erythrocytosis), which can result in an increased mean cell volume (MCV) or larger-sized red blood cells (macrocytosis).
Additionally, PRV is not associated with low erythrocyte sedimentation rate (ESR). ESR is a non-specific marker of inflammation that is typically elevated in various inflammatory conditions, but it is not directly related to the size of red blood cells.
It’s important to note that microcytosis and low ESR are more commonly associated with a different condition called iron deficiency anemia. Iron deficiency anemia is characterized by a decrease in the production of hemoglobin, resulting in smaller-sized red blood cells and low iron stores. It can also lead to a decreased ESR due to reduced red blood cell aggregation.
Therefore, if microcytosis and low ESR are observed, it is more likely to be indicative of iron deficiency anemia rather than polycythemia rubra vera. However, the diagnosis and interpretation of these findings should be made by a healthcare professional based on the patient’s specific clinical presentation, laboratory results, and further investigations if necessary.