An elderly multiparous woman with intrauterine foetal death was admitted with strong labour pains
The patient suddenly goes in shock with cyanosis respiratory disturbances and pulmonary oedema
acquired hemophilia
1.Inherited congenital hemophilia: Is extremely rare in females.
It is an x linked disorder seen mainly in males.
2.Acquired hemophilia :It is a disorder in which antibodies develop against coagulation factors.
Antibodies can develop against one coagulation factor or several factors.
The most common target protein is factor VIII.
Anti-factor VIII antibodies are seen in:
– Hemophiliacs (apart from the congenital factor VIII or IX def i ciency) – Post partum females – Due to drugs – SLE – Normal elderly individuals yy The patient in the question is a post –partum female who has developed antibodies against factor VIII (i.e. she is a case of Acquired hemophilia).
The patients coagulation prof i le matches exactly with that of acquired hemophilia conf i rming our diagnosis