Beri beri -Thiamine deficiency

Beri beri -Thiamine deficiency

Dry beriberi- nerve damage ending in muscular paralysis

Wet beriberi - 3 stages

Peripheral vasodilation causing high cardiac output state. Contributes to salt and water retention via RAS. Secondary fluid is also absorbed into the circulatory system.
The resulting fluid overload leads to edema of the dependent extremities.

By the time significant edema occurs, the heart has been exposed to a severely high workload in order to pump the required cardiac output needed to satisfy end organ requirements.
Heart muscle undergoes overuse injury, which results in the physical symptoms of tachycardia, edema, and high arterial and venous pressures.

Hence Diuretics are preferred as an addon therapy to correct fluid overload.