Criteria for Four Categories of the Systemic Infammatory Response Syndrome
1- SIRS; Two or more of the following:
• Temperature (core) >38°C or <36°C
• Heart rate >90 beats/min
• Respiratory rate >20 breaths/min for patients spontaneously ventilating or a PaCO2 <32 mm Hg .
• WBC count >12,000 cells/mm3 or <4000 cells/ mm3 or >10% immature (band) cells in the peripheral blood smear
2- Sepsis;
• Same criteria as for SIRS but with a clearly established focus of infection
3-Severe Sepsis;
• Sepsis with organ dysfunction and hypoperfusion
• Indicators of hypoperfusion:
- Systolic BP <90 mm Hg
-
40 mm Hg fall from normal systolic blood pressure
- Lactic acidosis
- Oliguria
- Acute mental status changes
4- Septic Shock;
• Patients with severe sepsis who:
- Are not responsive to IV fuid infusion for resuscitation
- Require inotropic or vasopressor agents to maintain systolic blood pressure