Electron micrograph showing endoplasmic reticulum dilated by aggregates of misfolded protein

α1-Antitrypsin deficiency.

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(A) Periodic acid–Schiff (PAS) stain after diastase digestion of the liver, highlighting the characteristic “magenta cytoplasmic granules”.

( B ) Electron micrograph showing endoplasmic reticulum dilated by aggregates of misfolded protein.