Healing of Clean Uninfected Wound:
-
Day 0
Presence of blood clot in incision/scab -
Day 1
Neutrophilic infiltration + blood clot -
Day 2
Neutrophils + blood clot + continuous thin epithelial layers -
Day 3
Macrophages replace neutrophils
Appearance of granulation tissue
Deposition of type III collagen -
Day 5
Abundant granulation tissue
Collagen fibrils bridge the incision
Neovascularization is maximum
Full epithelial thickness with surface keratinization -
End of 2nd week
Accumulation of collagen
Fibroblast proliferation
Disappearance of leucocyte inflammation -
1 month
Replacement of collagen type III with collagen type I
Dermal appendages are lost