• fatal syndrome that has detrimental effects to organs, especially the brain and liver
• lower level of blood sugar (hypoglycemia).
• classic features are a rash, vomiting, and liver damage.
• Unknown etiology but associated with aspirin consumption by children with viral illness, it also occurs in the absence of aspirin use
• LABORATORY TESTS:-
• elevated liver enzymes, elevated ammonia levels, and low serum glucose levels.
• HISTOLOGIC CHANGES:-
• All cells have pleomorphic, swollen mitochondria that are reduced in number ( diagnostic finding)
• Liver — fatty liver with minimal inflammation (Microvesicular Steatosis ) and glycogen depletion.
• Hepatic mitochondrial dysfunction results in hyperammonemia, which is thought to induce astrocyte edema, resulting in cerebral edema and increased intracranial pressure (ICP).