SLE and Autoantibodies🌸
Most sensitive antibody – ANA ( Anti-Nuclear Antibody)
Most specific antibody – anti Sm (smith) antibody
Most sensitive and specific both – anti dsDNA antibody.
Drug induced Lupus- anti-histone antibodies.
Most specific antibody in “Neonatal lupus with congenital Heart block” is Anti Ro (SS-A)
Antibody in SLE predisposes to photo toxicity – anti-RO (=SS-A) antibody.
“Shrinking lung syndrome” is characteristically associated with anti-RO (=SS-A) antibody.
Reynaud’s phenomenon in SLE is associated with antiU1 ribonucleoprotein (anti-U1 RNP) antibody.
Neuropsychiatric features are associated with Antiribosomal-P antibody.