Steatosis means -
-
- Accumulation of protein
-
- Accumulation of triglyceride
-
- Accumulation of glycogen
-
- Accumulation of pigment
0 voters
exp:
Intracellular accumulation
- One of the manifestations of metabolic derangements in cells is the intracellular accumulation of abnormal amounts of various substances.
- It implies the storage of some product by individual cell.
- Intracellular accumulation fall into three categories.
- A normal constituent is accumulated in excess such as water, lipids, proteins, Carbohydrates.
- An abnormal substance either exogenous (e.g., mineral) or endogenous (e.g., product of abnormal metabolisms), is accumulated in excess.
- Pigment is accumulated.
-
Pathogenesis of intracellular accumulation
Intracellular accumulation may occur by any of the three abnormalities :
- A normal endogenous product is produced at a normal rate, but the rate of metabolism is inadequate to remove it, e.g., fatty change (steatosis) in liver.
- A normal or abnormal endogenous product is accumulated becuase of genetic or acquired defects in the metabolism, packaging or transport of these substances e.g., lysosomal storage diseases.
- An abnormal exogenous substance is deposited and accumulates because the cell has neither the enzymatic machinery to degrade the substance nor the ability to transfer it to other sites.
Fatty change (Steatosis)
- The term steatosis (fatty change) describe abnormal accumlation of triglyceride within parenchymal cells.
- Liver is involved most commonly. Other organs involved are heart and kidney.
- In all organs fatty change appears as clear vacuoles within parenchymal cells. In heart, alteration of yellowish streaks (fatty change) and reddish streaks (unaffected myocardium) gives tigeroid or tabby cat appearance.
- To identify fat, frozen tissue sections are stained with Sudan IV or oil Red 0 which give orange red colour.