The APTT …If prolonged , first exclude heparin therapy .
Prolonged APTT+ PT+ low fibrinogen >>> think in DIC or dilutional DIC ( after massive fluid and packed RBC transfusions ) .
Prolonged APTT + thrombosis >>> lupus anticoagulant , with APL syndrome .
Prolonged APTT+ low factor 8 + only male bleeder >>> hemophilia
Prolonged APTT or normal + normal or reduced factor 8 + female bleeder >>> think in vW disease .
Prolonged APTT +not corrected with 50% mixing + bleeding >> factor 8 inhibitors .