Therapy of Brugada syndrome:

Cardiac arrest or syncope in the presence of a diagnostic ECG are indications for ICD.

The decision to implant an ICD should be weighted against a reported 36% risk of complications such as lead failure and inappropriate shocks.

Quinidine, a drug with I to blocking properties, has been successfully tried, but the evidence for its widespread use is not sufficient. Quinidine-induced diarrhoea is treated with colestyramine.

Catheter ablation over the epicardial RVOT has been recently reported to result in normalization of the Brugada ECG pattern and prevent clinical and inducible VT/VF.

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