56-yr-old man, known to have HIV presents to E&A following two consecutive seizures. He is on HAART for last two years. CT scan (without contrast) shows a single lesion in the left paraventricular region.
What is the best way to differentiate between lymphoma and toxoplasmosis?
A. CT with contrast
B. MR spectroscopy
C. Thallium SPECT
D. Examination of buffy coat
E. Lumber puncture