A 22-year-old man has a raised, pigmented lesion on his forearm that has increased in size and become more irregular in color over the past 4 months.
Physical examination shows a 0.5 × 1.2 cm black-to-brown asymmetric lesion with irregular
borders. An excisional biopsy specimen shows clusters of pleo morphic pigmented cells that extend into the reticular dermis.
Family history indicates that the patient’s maternal uncle died from a similar tumor. His grandfather required enucleation of the left eye because of a “dark brown” retinal mass.
Which of the following genes is most likely to have undergone mutation
to produce these findings in this family?
Lyn (tyrosine kinase gene)