A 56-year-old man with chronic alcoholism visits his physician for help with his addiction. He
has been taking naltrexone for the past four months as instructed. But he feels that instead of
naltrexone helping him, he has been building up a tolerance to it. Now he is reverting back to
his old ways and would like a stronger medication. Disulfiram is prescribed. What is the
mechanism of action of this new drug?
- A. Alcohol dehydrogenase agonist
- B. Alcohol dehydrogenase antagonist
- C. Acetaldehyde dehydrogenase agonist
- D. Acetaldehyde dehydrogenase antagonist
- E. Increase excretion of acetic acid
0 voters
A 31-year-old woman with chronic alcoholism returns to her physician for help. She has been
taking naltrexone for the past three months as instructed, but she feels that instead of it
helping her, she has been building up a tolerance to it. Now she is reverting back to heavy
drinking. The physician prescribes disulfiram. What is a side effect of this new drug?
- A. Nausea and vomiting
- B. Decreased sexual ability
- C. Neck pain
- D. heachache
- E. Shortness of breath
0 voters
A 37-year-old woman visits her physician because of unusual physical changes. She is a
jogger and notes that her sneaker size has been steadily increasing. Her winter gloves that
she has worn for years now seem a little tight. She also notices moderate weight gain despite
being active. Physical examination otherwise reveals no obvious abnormalities. Serum lab
results are shown.
Sodium: 139 mmol/L
Potassium: 4.0 mmol/L
Glucose: 123 mg/dL
Insulin-like growth factor-1 (IGF-1): 1327 ng/mL
Cortisol: 10 ug/dL
Oral glucose is given and no apparent changes in IGF-1 are seen. What is the most likely
underlying condition?
- A. Pre-diabetes mellitus
- B. Atrophy of pancreatic β-islets
- C. Pituitary macroadenoma
- D. Pituitary adenocarcinoma
- E. Ectopic releasing hormone secretion
0 voters