A 59-year-old man has noticed blood in his urine for the past week.
Cystoscopy shows a 4-cm exophytic mass involv ing the right bladder mucosa near the trigone.
After biopsy specimens are obtained, he undergoes a radical cystectomy.
Examination of the excised specimen shows an anaplastic car cinoma that has infiltrated the bladder wall.
Immunohistochemistry