MAY 2014
37.In the entire genome, the coding DNA constitutes how much (AIIMS 2014 May)
a) 1%
b) 2%
c) 0.1%
d) 4%
Current estimate is~1%(0.01) is exonic DNA
Haploid genome is 3x109
bp of DNA.
1…Final acceptor of electrons in ETC is(AIIMS 2014 May)
a) Cyt c
b) Oxygen
c) FADH2
d) CoQ
Oxygen accept e- and it is reduced to water.
2.Enzyme common to both Glycogenesis and Glycogenolysis is( AIIMS May 2014)
a) Glycogen Synthase
b) Glycogen Phosphorylase
c) Glucan Transferase
d) PhosphoGluco Mutase
Enzymes of Glycogen Synthesis & Glycogenolysis
3.Methylation of Cytidine residues of DNA will cause(AIIMS 2014 May)
a) No Change
b) Decrease gene expression
c) Mutation
d) Increase in gene expression
DNA Methylation
Generally decreases the gene expression or Gene silencing
DNA Demethylation
Generally increases the gene expression .
4.Which of the following is not an intermediate of TCA Cycle? (AIIMS 2014 May)
a) Acetyl CoA
b) Citrate
c) Succinyl CoA
d) Alpha Keto Glutarate
Acetyl CoA and Oxaloacetate are the starting materials of TCA Cycle.
First substrate of TCA cycle is Oxaloacetate
5.Which of these disease can be treated by enzyme replacement?
a) Gaucher’s Disease
b) Fabry’s Disease
c) Pompe’s disease
d) Sanfilippo Disease
Gauchers Disease
Recombinant Human Acid Beta Glucosidase( Imiglucerase)
Velaglucerase alfa
Taliglucerase alfa
Fabry’s Disease
Recombinant α-galactosidase (Agalzidase β orFabrazyme)
Agalzidase α (Replagal)
Pompe’s Disease
Recombinant human acid α-glucosidase (alglucosidase alfa, (Myozyme)
6.In the crystalline lens, level of tocopherol and Ascorbate is maintained by(AIIMS 2014 May)
a) Glutathione
b) Glyoprotein
c) Fatty Acid
d) Glucose
Answer: a, Glutathione
7.2,3 DPG binds to ___ sites in hemoglobin & causes ___in its oxygen affinity (AIIMS 2014 May)
a) four, increases
b) four, decreases
c) one, increases
d) one , decreases
The hemoglobin tetramer binds one molecule of BPG in the central cavity formed by its four subunits.
Elevated BPG lowers the affinity of HbA for O2 (increases P50), which enhances the release of O2 at peripheral
tissues.
One Hb binds to 4 mols Oxygen and but one mol of 2,3 DPG.
Hb F has low affinity towards 2,3 BPG.
8.Which of the following disease is not caused by Uniparental Disomy? (AIIMS 2014 May)
a) Angelman Syndrome
b) Praderwilli Syndrome
c) Bloom’s Syndrome
d) Russel Silver Syndrome