An angina drug with a half life of 3 hours has been found safe in initial test studies on healthy volunteers and a small trial of patients. What trial should be used next?

An angina drug with a half life of 3 hours has been found safe in initial test studies on healthy volunteers and a small trial of patients. What trial should be used next?

    1. Cross sectional study
    1. Prospective cohort study
    1. Double blind parallel group randomised control trial
    1. Double blind crossover randomised control trial
    1. Open label cross over study

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EXP:

For a new treatment a randomised control trial is the best way to verify its effectiveness. A cross over study provides better results when comparing treatments but can only be used if a treatment is not disease modifying.