Pilomatricoma
(Calcifying Epithelioma of Malherbe)
Clinical
Deep-seated, frequently calcified nodules on the head,
neck and upper extremities of children and young
adults
These lesions may be solitary or multiple (autosomal
dominant inheritance) or may be a marker of a
systemic disease (Gardner’s syndrome)
Microscopic
A cystic or multinodular tumor with a biphasic
epithelial growth pattern consisting of eosinophilic,
ghosts or shadow cells centrally and basophilic,
basaloid cells peripherally
Granulomatous inflammation and calcification are
frequent and may obscure the characteristic growth
pattern