Drug of choice for invasive aspergillosis
is
a) Posaconazole
b) Voriconazole
c) Liposomal AMB
d) Caspofungin
Correct Answer - B
Ans: B. Voriconazole
The preferred treatment of primary IA is voriconazole, which has
been found to be superior to amphotericin B.
Azoles interfere with the synthesis of ergosterol found in the fungal
cell membrane, whereas polyenes – such as amphotericin B –
interfere with ergosterol function.
An echinocandin that disrupts fungal cell wall synthesis –
caspofungin – and itraconazole have been approved for salvage
therapy of IA.
Ref: Treatment options in Invasive Aspergillosis - PMC