Edema, proteinuria, hyperlipidemia (317/1700)

A 44yo man presents with periorbital and pedal edema. 24h urine shows 8g of protein/d and
serum cholesterol=7mmol/L. Renal biopsy results are awaited. What would be the most likely dx?

a. Minimal change disease
b. Glomerulonephropathy
c. Membranous glomerulonephropathy
e. IgA nephropathy
f. Mesangiocapillary

answer: C

Nephrotic syndrome: PALE
Proteinuria > marked
Albumin low
Lipids high

causes: in order of most proteinuria
• Minimal change GN …commonest cause in children
• Membranous GN…commonest cause of in adults