Fenton reaction leads to free radical generation when -
1.Ferrous ion converted to ferric ion
2.Radiant energy is absorbed by water
3.H2o2 is formed by myeloperoxidase
4.Nitric oxide is coverted to peroxynitrite
exp:
o Free radicals are generated through Fenton’s reaction.
o In this reaction iron is converted from its ferrous to ferric form and a free radical is generated,
o The effect of these reactive species relevant to cells injury include;
Lipid peroxidation of membranes
Oxidative modification of proteins and lesions in DMA.