Fluoroquinolone contraindicated in liver
disease is
a) Levofloxacin
b) Pefloxacin
c) Ofloxacin
d) Lomefloxacin
Correct Answer - B
Ans: B. Pefloxacin
Pefloxacin has longer t½: accumulates on repeated dosing
achieving plasma concentrations twice as high as after a single
dose.
Because of this, it is effective in many systemic infections as well.
The dose of pefloxacin needs to be reduced in liver disease, but not
in renal insufficiency.
Ref: K. D. Tripathi 7th Edition. Page. 713