Gall bladder carcinoma


More common in Females

Mostly in the 7th decade of life

Risk factors

Gall stones – most important risk factor (↑size and duration, ↑ risk)

Porcelain Gall Bladder

Choledochal cyst

Chronic typhoid carriers


Cholesterosis of gall bladder (strawberry GB)

Clinical features

Nonspecific – indistinguishable from benign gall bladder disease like biliary colic or cholecystitis

Jaundice(less common), significant weight loss in short duration

CA 19-9 is elevated in 80%; CEA is also elevated in few cases

Diagnosis confirmed by multidetector row CT scan


Adenocarcinoma is the me type (90%)

The tumor is most commonly nodular and infiltrative, with thickening of the gall bladder.

Nevin’s staging


II. Spread to muscularis

III. Spread to serosa

IV. Spread to cystic lymph node of Lund (the sentinel node)

V. Direct spread to adjacent organs/Distant metastases


Stage I and II - simple cholecystectomy

Stage III – cholecystectomy + adjacent hepatic resection (atleast 2cm depth) + regional lymphadenectomy

Poor prognosis