A patient aged 65 years, is diagnosed to have severe aplastic anemia. HLA compatible sibling is available. The best option of treatment is;
a) Anti thymocyte globulin followed by cyclosporine
b) A conventional bone marrow transplantation from the HLA identical sibling
c) A non-myeloablative bone marrow transplantation from the HLA identical sibling
d) Cyclosporine
Correct answer : a) Anti thymocyte globulin followed by cyclosporine
Treatment of choice in an elderly individual with severe aplastic anemia is immunosuppression – Anti thymocyte globulin followed by cyclosporine. Bone marrow transplantation is tried only in young adults.
ln acute pulmonary embolism, the most frequent ECG finding is:
a) S1Q3T3 pattern
b) P. pulmonale
c) Sinus tachycardia
d) Right axis deviation
Correct answer : c) Sinus tachycardia
All of the above features may be seen in acute pulmonary embolism, but sinus tachycardia is seen in all cases.
A hoursewife ingests a rodenticide white powder accidentally. She is brought to hospital where the examination shows generalized, flaccid paralysis and an irregular pulse. ECG shows multiple ventricular ectopics, generalized changes with ST-T. Serum potassium is 2.5 m Eq/L. The most likely ingested poison is:
a) Barium carbonate
b) Super warfarins
c) Zinc phosphide
d) Aluminium phosphide
Correct answer : a) Barium carbonate
Read more : Features of barium carbonate poisoning
The endotoxin of the following gram negative bacteria does not play any part in the pathogenesis of the natural disease:
a) Escherichia coli
b) Klebsiella sp.
c) Vibrio cholerae
d) Pseudomonas aeruginosa
Correct answer : c) Vibrio cholerae
Vibrio cholerae exotoxins are responsible for it’s pathogenicity.
Salmonella typhi is the causative agent of typhoid fever. The infective dose of S. typhi is:
a) One bacillus
b) 10(8) – 10(10) bacilli
c) 10(2) – 10(5) bacilli
d) 1-10 bacilli
Correct answer : c) 10(2) – 10(5) bacilli (factual question)
The single most common cause of pyrexia of unknown origin is:
a) Mycobacterium tuberculosis
b) Samonella typhi
c) Brucella sp.
d) Salmonella paratyphi A
Correct answer : a) Mycobacterium tuberculosis (factual question)
“lntestinal angina” is a symptom complex of the following:
a) Postprandial abdominal pain, weight loss, actue mesenteric vessel occlusion
b) Postprandial abdominal pain, weight loss, chronic mesenteric vessel occlusion
c) Preprandial abdominal pain, weight loss, chronic mesenteric vessel occlusion
d) Preprandial abdominal pain, weight gain, acute mesenteric vessel occlusion
Correct answer : b) Postprandial abdominal pain, weight loss, chronic mesenteric vessel occlusion
Intestinal angina is due to chronic mesenteric vein occlusion. It causes abdominal pain, cramping following food intake, weight loss and chronic diarrhoea
A 45-year old woman underwent a modified radical mastectomy 4 years ago. She was treated for multiple bone metastases with cyclophosphamide, doxorubicin, and fluorouracil for 6 months. She is complaining of breathlessness on exercise, swelling of the legs, and swelling around eyes in the morning. On examination, she has bilateral rales in the lungs, S3 gallop present. What is the most likely cause for her cardiac condition?
a) Diastolic heart failure
b) Drug induced cardiac toxicity
c) Metastatic cardiac disease
d) Pneumonia
Correct answer :
b) Drug induced cardiac toxicity
Explanation : Doxorubicin is known to cause cardiotoxicity. Read more : Doxorubicin induced cardiotoxicity
Which of the following statements is correct regarding adrenal histoplasmosis:
a) In active disease, calcification is commonly seen
b) Lymphadenopathy is not seen
c) The adrenal glands are usually symmetrically enlarged
d) Adrenal insufficiency is uncommon
Correct answer : c) The adrenal glands are usually symmetrically enlarged
Explanation : Adrenal histoplasmosis