In advanced patients of Parkinsonism, which is more preferred?( Levodopa + Carbidopa) or D2 agonists?

NEET PG
#1

In advanced patients of Parkinsonism, which is more preferred?( Levodopa + Carbidopa) or D2 agonists?

Ropinirole / pramipaxol

Less tha 65 yrs with effect on quality of life - d2 receptor agonist

More than 65yrs - levodopa

Since you are asking about the Advanced cases,That means Parkinsonism is affecting his/her Quality of Life, So for that Age parameter is taken into consideration.

(A) For <65 Years= Its D2 Agonist(Reason being S/E is Somnolence, Fatigue etc which are highly undesirable in Older Individuals).

(😎 For >65 Years= Levodopa(As Levodopa S/E is Psychosis, DYSKINESIA. And Dyskinesia is Highly Undesirable in Younger Individuals. So Given in older age.)