in folic acid deficiency as b12 is given along, is this senario vice versa that is in b12 deficiency folic acid
aB12 and folate deficiency should ideally be treated with supplementation of that particular hormone only; not in combo.
Folate supplementation in a case of B12 deficiency can rapidly use all B12 for thymidylate (UMP - TMP) reaction and therefore neurological status would worsen as B12 can’t transform neurotoxic methyl-malonyl CoA into succinyl CoA.lso given along
No as in vit b12 deficiency if we add folate then the folate.triggers the small.vitb12 into the dna synthesis pathway and thus the methyl Malonyly pathway is more jeopardized thus leading.to increase in neurological.symptoms.of patient
Please find that during correction of vitamin B12 deficiency, folic acid is given to keep up with the increasing erythropoiesis as a result of treatment.
Correction of folate deficiency is done with folic acid only. Vitamin B12 is given with folic acid deficiency only in case of concomitant vitamin B12 deficiency.
Folic acid should never be given alone to patients with vitamin B12 deficiency, because an increase in erythropoiesis occur as a response, but neurological defect may worsen due to diversion the already low amount of vitamin B12 present in body to haematopoiesis.