Irreversible cell injury is indicated by -

NEET PG Pathology
#1

Irreversible cell injury is indicated by -[poll type=multiple min=1 max=4 public=true]

    1. Accumulation of calcium in mitochondria
    1. Myelin figures
    1. ATP depletion
    1. Shifting of ribosomes
      [/poll]

exp:

  • Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note :
  • Small (not large) phospholipid rich amorphous densities are found in reversible injury.