Malignant triton tumor (mtt)


■ Malignant triton tumor (MTT) is a rare, aggressive tumor

■ Made up of both malignant schwannoma cells and malignant rhabdomyoblasts.

■ It’s classified as a malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation.

■ MPNST (Malignant Peripheral Neural Sheath Tumour) with well developed skeletal muscle component

● Diagnostic criteria of Woodruff :
1)Tumor arises along a peripheral nerve, in a ganglioneuroma, in NF1 patient, or is a metastasis from such a tumor
2) Tumor has characteristics of Schwann cell tumor
3) Rhabdomyoblasts arise from body of tumor

■ Malignant triton tumors are stained ------ for desmin, myoglobin and S-100 protein.