Most common cause of hypercalcemic crisis is

A hypercalcaemiccrisisis an emergency situation with a severehypercalcaemia, generally above approximately 14 mg/dL (or 3.5 mmol/l)
The most common cause is hypercalcemia of malignancy,
although granulomatous diseases, previously undetected primary hyperparathyroidism, medication-induced hypercalcemia, and a few rarer
causes may result in this endocrine emergency as well.

Stepwise approach for management of

Hypercalcemic crisis
Step 1:

Confirm the diagnosis.

Step 2:

Restore normal hydration - Through IV fluids(200-500 ml/hr of NS )should be administered to maintain a urine output of >100 ml/hr.

Step 3:

• Use of loop diuretics to be limited to
hypercalcemic crisis associated with heart failure or renal failure.
Calcitonin or bisphosphonates-Preferred drugs for hypercalcemic management after restoring normal hydration with IV fluids.