CHOLANGIOCARCINOMA
Mucin producing adenocarcinomas that arise from bile ducts
Types: intrahepatic, hilar or central (65%) and peripheral (30%)
Nodular tumors arising at the bifurcation of the common bile duct are called Klatskin tumors and are often associated with a collapsed gallbladder
Predisposing factors
Primary sclerosing cholangitis
Hepatolithiasis
Fibropolycystic liver disease
Caroli disease (bile duct ectasia)
Alcoholic liver disease
Choledochal cyst
Choledocholithiasis
HBV, HCV infection
Thorotrast exposure(formerly used in radiography of biliary tree)
Opisthorchis viverrini and Clonorchis sinensis infestation
Premalignant lesions
Biliary intraepithelial neoplasia (BiIIN 1, 2,3)
Mucinous Cystic Neoplasm
Intraductal Papillary Biliary Neoplasia
Clinical features, diagnosis and treatment
Typically presents with painless jaundice often with pruritis and weight loss
CEA, CA 19-9, and CA-125 are often elevated in CCC patients and are useful for following response to therapy