Neonatal thymectomy leads to

NEET PG Microbiology
#1

Neonatal thymectomy leads to -

    1. Decreased size of germinal center
    1. Decreased size of paracortical areas
    1. Increased antibody production by B cells
    1. Increased bone marrow production of lymphocytes

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T cells origin and maturation

  • T cells originate in the bone marrow, fetal liver and yolk sac and mature in thymus.

  • T cell precursors from the yolk sac, fetal liver and bone marrow migrate to the thymus during embryonic and postnatal life.

  • Maturity of T-cells takes place in the thymus.

  • After maturity T-lymphocytes are selectively seeded into certain sites of the peripheral lymphatic tissues, known as “thymus - dependent regions”.

  • Thymus dependent regions are -

  • Paracortical area of lymph node.

  • White pulp of the spleen, around the central arteriole.

  • After neonatal thymectomy, the source of mature T cells (thymus) will be absent. As a result the thymus dependent regions of peripheral lymphoid organs will be depleted of T cells.