Rarest type of Von Willebrand disease :
a) vWD type 1
b) vWD type 2A
c) vWD type 2N
d) vWD type 3
Correct Answer - D
Ans. is ‘d’ i.e., vWD type 3
ConditionDefect
vWD
type 1
Mild to moderate quantitative
deficiency of vWF (ie, about 20-
25% of normal levels).
vWD
type 2A
The most common qualitative
abnormality of vWF, is associated
withselective loss of large and
medium-sized multimers
vWD
type 2B
Loss of only large multimers as
mutant vWF spontaneously binds
to Gplb in the absence of
subendothelial contact
vWD
type 2N
Characterized by a defect residing
within the patient 's plasma vWF
that interferes with its ability to
bind FVIII
vWD
type 2M
Involves qualitative variants with
decreased platelet-dependent
function not resulting from
absence of highmolecular weight
multimers
WD
type 3
A severe, quantitative deficiency
associated with very little or no
detectable plasma or platelet
vWF, have a profound bleeding
disorder