Recurrent respiratory papillomatosis is treated locally by
acyclovir
cidofovir
zinc
ranitidine
Answer: B. Mechanical/laser removal of the papillomatous lesions combined with cidofovir injection, control visits and indirect laryngoscopy (stroboscopy) in outpatient clinic every 4–6 weeks, immediate hospitalization, and another surgical procedure in suspicion of recurrence.
Maximum total dose of cidofovir should not exceed 3 mg/kg.
Due to high toxicity of cidofovir,analysis of laboratory parameters like morphology with blood smear, urea, creatinine, ALT, AST, and bilirubin levels before the treatment, 1 day and 4 weeks after the injection.
All papillomas should be examined histopathologically to exclude any dysplastic features or malignant transformation.