Regarding NK cells, false statement is

Regarding NK cells, false statement is -

    1. It is activated by IL -2
    1. Expresses CD3 receptor
    1. It is a variant of large lymphocyte
    1. There is antibody induced proliferation of NK cells

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Null cells (Large granular lymphocytes)

  • Null cells are called so because they lack features of surface markers of both B and T lymphocytes.

  • The account for 5 to 10% of peripheral blood lymphocytes.

  • They are also called “large granular lymphocytes (LGL)” as they contain large azurophilic cytoplasmic granules.

  • They express

  • Surface receptors for the Fc portion of IgG (CD-16)

  • NCAM-I (CD56)

  • They proliferate in response to IL-2

  • Many LGL express some lineage marker particularly CD-8, CD-2.

  • LGLs arise in both bone marrow and thymic microenvironment.

  • Members of this group are :

  1. Antibody dependent cytotoxic cells (ADCC)
  2. Natural killer cells (NK cells)
  3. Lymphokine activated Killer (LAIC) cells