Regarding NK cells, false statement is -
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- It is activated by IL -2
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- Expresses CD3 receptor
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- It is a variant of large lymphocyte
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- There is antibody induced proliferation of NK cells
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Null cells (Large granular lymphocytes)
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Null cells are called so because they lack features of surface markers of both B and T lymphocytes.
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The account for 5 to 10% of peripheral blood lymphocytes.
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They are also called “large granular lymphocytes (LGL)” as they contain large azurophilic cytoplasmic granules.
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They express
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Surface receptors for the Fc portion of IgG (CD-16)
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NCAM-I (CD56)
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They proliferate in response to IL-2
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Many LGL express some lineage marker particularly CD-8, CD-2.
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LGLs arise in both bone marrow and thymic microenvironment.
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Members of this group are :
- Antibody dependent cytotoxic cells (ADCC)
- Natural killer cells (NK cells)
- Lymphokine activated Killer (LAIC) cells