The criteria for SLE

NEET PG
#1

CLINICAL CRITERIA IMMUNOLOGIC CRITERIA

  1. Acute Cutaneous Lupus OR
    Subacute Cutaneous Lupus 1) Increased ANA Level.
  2. Chronic Cutaneous Lupus 2) Increased Anti-dsDNA antibody
    level
  3. Oral Ulcers OR Nasal Ulcers 3) Increased Anti-Sm antibody level
  4. Nonscarring alopecia 4) Antiphospholipid antibody
    positivity.
  5. Synovitis involving 2 or more
    joints
    5) Low complement (C3, C4, or CH50)
  6. Serositis 6) Direct Coombs’ test (in the absence of hemolytic anemia)
  7. Renal
  8. Neurologic
  9. Hemolytic anemia
  10. Leukopenia (<4000/mm3) OR
    Lymphopenia (<1000/mm3)
  11. Thrombocytopenia
    (<100,000/mm3)

A) CLINICAL CRITERIA:-

(1) Acute Cutaneous Lupus OR Subacute Cutaneous Lupus
• Acute cutaneous lupus: lupus malar rash (do not count if malar discoid),
bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular
lupus rash, photosensitive lupus rash (in the absence of dermatomyositis)
• Subacute cutaneous lupus: nonindurated psoriaform and/or annular
polycyclic lesions that resolve without scarring, although occasionally with
postinflammatory dyspigmentation or telangiectasias)

(2) Chronic Cutaneous Lupus
• Classic discoid rash localized (above the neck) or generalized (above and
below the neck), hypertrophic (verrucous) lupus, lupus panniculitis
(profundus), mucosal lupus, lupus erythematosus tumidus, chillblains lupus,
discoid lupus/lichen planus overlap

(3) Oral Ulcers OR Nasal Ulcers
• Oral: palate, buccal, tongue
• Nasal ulcers
In the absence of other causes, such as vasculitis, Behcet’s disease, infection
(herpesvirus), inflammatory bowel disease, reactive arthritis, and acidic foods

(4) Nonscarring alopecia
• Diffuse thinning or hair fragility with visible broken hairs, in the absence of
other causes such as alopecia areata, drugs, iron deficiency, and androgenic
alopecia

(5) Synovitis involving 2 or more joints

• Characterized by swelling or effusion ,OR tenderness in 2 or more joints and
at least 30 minutes of morning stiffness

(6) Serositis

• Typical pleurisy for more than 1 day OR pleural effusions OR pleural rub
• Typical pericardial pain (pain with recumbency improved by sitting forward)
for more than 1 day OR pericardial effusion OR pericardial rub OR
pericarditis by electrocardiography.
• In the absence of other causes, such as infection, uremia, and Dressler’s
pericarditis

(7) Renal

• Urine protein–to-creatinine ratio (or 24-hour urine protein) representing 500
mg protein/24 hours OR red blood cell casts

(8) Neurologic

• Seizures, psychosis, mononeuritis multiplex(in the absence of other known
causes such as primary vasculitis), myelitis, peripheral or cranial neuropathy
(in the absence of other known causes such as primary vasculitis, infection,
and diabetes mellitus), acute confusional state (in the absence of other
causes, including toxic/metabolic, uremia, drugs)

(9) Hemolytic anemia

(10) Leukopenia (<4000/mm3) OR Lymphopenia (<1000/mm3)

• Leucopenia at least once: In the absence of other known causes such as
Felty’s syndrome, drugs, and portal hypertension.
• Lymphopenia at least once: in the absence of other known causes such as
corticosteroids, drugs, and infection

(11) Thrombocytopenia (<100,000/mm3)

• At least once in the absence of other known causes such as drugs, portal
hypertension, and thrombotic thrombocytopenic purpura.