Therapy of Long QT syndrome:
Beta blockers should be administered to all intermediate or high-risk affected individuals and considered in low-risk patients, unless there is a contraindication. β adrenergic blockade may not shorten QTc at rest but suppresses cardiac events in LQT1 and LQT2, although the efficacy of β blockade is reduced in LQT2 possibly due to the resultant bradycardia.
Although no randomized comparative data exist, there has been observational evidence that propranolol and nadolol are preferred over metoprolol.
