Use of Anti-D immunoglobulin for Rhesus D prophylaxis:
1- Ectopic pregnancy : Anti-D immunoglobulin should be given to all non-sensitised RhD negative women who have an ectopic pregnancy
2- spontaneous miscarriage: Anti-D should be given to all non-sensitised RhD negative women who have spontaneous complete or incomplete abortion after 12 weeks of pregnancy.
Anti-D lg should be should be given to such women prior to 12 weeks when there has been an intervention to evacuate the uterus
3- threatened miscarriage: Anti-D immunoglobulin should be given to all non-sensitized RhD negative women with a threatened miscarriage after 12 weeks of pregnancy.
Where bleeding continues intermittently after 12 weeks’ gestation , anti-D immunoglobulin should be given at 6-weekly intervals.
Routine administration of Anti-D lg in threatened miscarriage befor 12 weeks is not recommended. However it may be prudent to administer anti-D where bleeding is heavy or repeated or where is associated with abdominal pain, particularly if these events occur at gestation approach 12 weeks.