Warthin-Finkeldey type of giant cells are pathognomonic of
[A] HSV1
[B] EBV
[C] Adenovirus
[D] Measles
Answer = [D] Measles, Warthin-Finkeldey giant cells (epithelium derived) pathognomonic of measles. (See below) Contain numerous nuclei scattered throughout the cytoplasm (Numbers may be upto 100) with uniform size/shape resembling nuclei of macrophages.
Associations >> Seen in chronic infective granuloma, leprosy and tuberculosis and in presence of foreign bodies.
• ha .
Langhan’s Giant Cell: Nuclear arrangement follows either of the patterens ie around periphery in the form of Horseshoe/incomplete ring or clustering at the two poles of the giant cell.
Associations >> Seen in presence of foreign bodies or infections.
Note >>> Langhan’s Giant Cells are NOT Pathognomonic for TB
Touton Giant Cells: The Touton giant cells are formed by fusion of foam cells and show ring like, wreath shaped arrangement of nuclei. Peripheral cytoplasm outside the nuclear ring has a foamy/vacuolated appearance central area has clear eosinophilic cytoplasm.
These cells are seen in
Fat necrosis
Xanthoma
Xanthogranulomas Dermatofibroma