A 16-year-old boy with type 1 diabetes mellitus was treated with a biphasic insulin preparation but achievement of good blood glucose control proved difficult. He was offered treatment with the insulin analogue, insulin lispro.
Which characteristic of insulin lispro might improve his glycaemic control?
A: low incidence of hypoglycaemia
B: low incidence of lipoatrophy at the injection site
C: low risk of immunogenic reaction
D: rapid onset of action
E: small injection volume
Correct answer: D Explanation Insulin lispro is a rapid-acting human insulin analogue and leads to lower postprandial glucose concentrations compared to biphasic insulin.