Which is not a 2nd generation anti–histaminic agent ?
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- Cetirizine
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- Cyclizine
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- Loratidine
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- Fexofenadine
0 voters
exp:
Antihistaminics may be classified into first generation and second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate blood brain barrier and possess additional anticholinergic properties which are lacking in second generation drugs. Cyclizine is a first generation whereas cetririzine, loratidine and fexofenadine are second generation drugs.