Which side effect is associated with spironolactone?
A. Alkalosis
B. Hirsutism
C. Hyperkalemia
D. Hypercalcemia
E. Hyperglycemia
Answer: C. Spironolactone blocks aldosterone receptors thereby inhibiting the production of Na+ channels in the collecting duct and is used as
a K±sparing agent because the reabsorption of Na+ in the CT is coupled
(indirectly) to the secretion of K+ ions. Hyperkalemia is characteristic of this
drug and may lead to clinical consequences at high doses, or if patients fail
to discontinue K+ supplements or ingest foodstuffs high in K+. Because Na+
reabsorption is associated with secretion of protons, spironolactone causes
retention of H+ ions, leading to acidosis. It has no significant effect on the
renal elimination of Ca2+ or on the plasma level; of glucose